HY-12071A LDN193189鹽酸鹽（的同義詞LDN193189鹽酸鹽; LDN-193189鹽酸鹽）機制：ALK
LDN193189鹽酸鹽技術參數：價格和可用性LDN193189鹽酸鹽
LDN193189鹽酸鹽M.Wt：442.94
LDN193189鹽酸鹽分子式：C25H23ClN6
LDN193189的鹽酸純度：>98％
LDN193189鹽酸貯存：貯存在-20℃2年
LDN193189鹽酸鹽CAS號：1062368-62-0
LDN193189鹽酸鹽溶解性：DMSO
生物活性LDN193189鹽酸：
LDN193189是一種高度有效的小分子BMP抑制劑;抑制BMP I型受體ALK2（IC50：nM的5個），ALK3（IC50：30納米）和ALK6（TGFβ1/BMP信令）和隨后的SMAD蛋白的磷酸化; LDN193189是有用的工具中的干細胞生物學。 LDN193189顯示在體內的臨床應用價值，抑制FOP和異位骨化和潛在的代理人在**非小細胞肺癌肺腫瘤具有重要意義。
HY-12071A LDN193189 hydrochloride (Synonyms LDN 193189 hydrochloride; LDN-193189 hydrochloride) Mechanisms:ALK LDN193189 hydrochloride M.Wt: 442.94 LDN193189 hydrochloride Formula: C25H23ClN6 LDN193189 hydrochloride Purity: >98% LDN193189 hydrochloride Storage: at -20℃ 2 years LDN193189 hydrochloride CAS No.: 1062368-62-0 LDN193189 hydrochloride Solubility: DMSO 5mg 10mg 50mg Biological Activity of LDN193189 hydrochloride: LDN193189 is a highly potent small molecule BMP inhibitor; inhibiting BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation; LDN193189 is useful tool in stem cell biology. LDN193189 shows significant in vivo clinical utility, inhibiting FOP and ectopic ossification and a potential agent in the treatment of NSCLC lung tumors