HY-12071A LDN193189盐酸盐（的同义词LDN193189盐酸盐; LDN-193189盐酸盐）机制：ALK
LDN193189盐酸盐技术参数：价格和可用性LDN193189盐酸盐
LDN193189盐酸盐M.Wt：442.94
LDN193189盐酸盐分子式：C25H23ClN6
LDN193189的盐酸纯度：>98％
LDN193189盐酸贮存：贮存在-20℃2年
LDN193189盐酸盐CAS号：1062368-62-0
LDN193189盐酸盐溶解性：DMSO
生物活性LDN193189盐酸：
LDN193189是一种高度有效的小分子BMP抑制剂;抑制BMP I型受体ALK2（IC50：nM的5个），ALK3（IC50：30纳米）和ALK6（TGFβ1/BMP信令）和随后的SMAD蛋白的磷酸化; LDN193189是有用的工具中的干细胞生物学。 LDN193189显示在体内的临床应用价值，抑制FOP和异位骨化和潜在的代理人在**非小细胞肺癌肺肿瘤具有重要意义。
HY-12071A LDN193189 hydrochloride (Synonyms LDN 193189 hydrochloride; LDN-193189 hydrochloride) Mechanisms:ALK LDN193189 hydrochloride M.Wt: 442.94 LDN193189 hydrochloride Formula: C25H23ClN6 LDN193189 hydrochloride Purity: >98% LDN193189 hydrochloride Storage: at -20℃ 2 years LDN193189 hydrochloride CAS No.: 1062368-62-0 LDN193189 hydrochloride Solubility: DMSO 5mg 10mg 50mg Biological Activity of LDN193189 hydrochloride: LDN193189 is a highly potent small molecule BMP inhibitor; inhibiting BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation; LDN193189 is useful tool in stem cell biology. LDN193189 shows significant in vivo clinical utility, inhibiting FOP and ectopic ossification and a potential agent in the treatment of NSCLC lung tumors