HY-13011 CH5424802（别名CH5424802）机制：ALK
价格和可用性CH5424802 CH5424802技术参数：
CH5424802 M.Wt：482.62
CH5424802分子式：C30H34N4O2
CH5424802纯度：> 98％
CH5424802贮存：贮存在-20℃2年
CH5424802 CAS号：1256580-46-7
CH5424802溶解性：DMSO≥13mg/mL水分<1.2mg/mL乙醇1.2mg/mL
生物活性CH5424802：
CH5424802是一种强效，选择性，可口服ALK抑制剂。它具有独特的化学脚手架，优惠的抗肿瘤活性，对癌症的ALK基因的改变，如非小细胞肺癌（NSCLC）细胞表达EML4-ALK融合和间变性大细胞**瘤（ALCL）细胞表达NPM-ALK融合在体内和体外。 CH5424802 ALK L1196M，对应网守突变赋予共同抵抗激酶抑制剂，抑制和阻断EML4-ALK L1196M驱动的细胞生长。
HY-13011 CH5424802 (Synonyms CH 5424802) Mechanisms:ALK CH5424802 Technical Data: Price and Availability of CH5424802 CH5424802 M.Wt: 482.62 CH5424802 Formula: C30H34N4O2 CH5424802 Purity: >98% CH5424802 Storage: at -20℃ 2 years CH5424802 CAS No.: 1256580-46-7 CH5424802 Solubility: DMSO ≥13mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL 5mg 10mg 25mg 50mg 200mg Biological Activity of CH5424802: CH5424802 is a potent, selective, and orally available ALK inhibitor. which with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo. CH5424802 inhibited ALK L1196M, which corresponds to the gatekeeper mutation conferring common resistance to kinase inhibitors, and blocked EML4-ALK L1196M-driven cell growth.