Aminopterin|氨基喋呤

Aminopterin氨基喋呤 Aminopterin ~98% (TLC), powder

说明：生化研究或者抗叶酸。
别名：氨基蝶翅素；4-氨基叶酸；4-Amino-PGA；4-Aminofolic acid；4-Aminopteroyl-L-glutamic acid
分子式：C 1 9H 2 0N 8O 5 分子量：440.41
CAS＃：54-62-6
外观：黄色针状结晶
特性：纯度：98% (TLC)
溶解性：可溶于2 M NaOH，参考浓度 50 mg/mL4 ℃可
储存1-2天。也可溶于DMSO，4℃可储存1-2天。
R：61-28 S：53-28-36/37-45
储存条件：-20℃
From Sigma A1784

氨基喋呤 Aminopterin Descriptions

Linkage More potent, but more toxic, than methotrexate.

Biochem/physiol Actions Folic acid antagonist. Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn,binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase.

Properties

Assay…………………….. ~98% (TLC)

form ………………………...powder

color………………………... yellow

solubility ……………… 2 M NaOH: 50 mg/mL Solutions may be stored for 1-2 days at 4°C.

DMSO: Solutions may be stored for 1-2 days at 4°C.soluble

abs…………………………. ε1M/261 nm, 0.1 M NaOH 25,700

ε1M/282 nm, 0.1 M NaOH 24,500

ε1M/373 nm, 0.1 M NaOH 8,100

storage temp. −20°C

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